Journal: American Journal of Medicine Open

Article Title: Prevalence and Clinical Burden of Idiopathic Dilated Cardiomyopathy in the United States

doi: 10.1016/j.ajmo.2023.100038

Figure Lengend Snippet: Estimation and validation of idiopathic DCM prevalence in the United States. ( A ) Flowchart diagram of study approach and results. Patients with a suspected dilated cardiomyopathy (DCM) were identified using three definitions: definition 1 required that the patient received at least 1 ICD-10 inpatient code for I42.0, or 2 I42.0 outpatient codes at least 30 days apart; definition 2 required only 1 instance of I42.0 in the clinical record; and definition 3 was constructed to capture potentially underdiagnosed patients with EHR features of nonischemic cardiomyopathy who may or may not have received an I42.0 code; see details in methods and Supplementary Table S1 . Definition 1 was validated by review of 1000 randomly selected cases with clinical notes, and the positive predictive value (PPV) of this definition to identify idiopathic DCM was determined at 46.3%. Using this PPV and projecting the case prevalence of suspected DCM to the unweighted US Census population yielded an idiopathic DCM estimate of 194,385 people, or 59 cases per 100,000 people. ( B ) Manual review of 1000 randomly selected clinical notes from cases meeting DCM definition 1 found that n = 463 (46.3%) cases were idiopathic. Each circle represents 10 individuals, and the proportion of each color reflects the proportion of cases assigned to the indicated clinical category by Optum-contracted clinicians. DCM with suspected secondary or extrinsic factors was detected in the notes of 462 cases.

Article Snippet: Rates of diabetes and hypertension (17.9% and 51.7%, respectively) were lower in the UK Clinical Practice Research Datalink cohort, relative to the DCM population in the US Optum EHR (27.39 and 55.05%, respectively).

Techniques: Biomarker Discovery, Construct

Journal: American Journal of Medicine Open

Article Title: Prevalence and Clinical Burden of Idiopathic Dilated Cardiomyopathy in the United States

doi: 10.1016/j.ajmo.2023.100038

Figure Lengend Snippet: Period Prevalence Rates of Dilated Cardiomyopathy and Extrapolated Clinical Burden

Article Snippet: Rates of diabetes and hypertension (17.9% and 51.7%, respectively) were lower in the UK Clinical Practice Research Datalink cohort, relative to the DCM population in the US Optum EHR (27.39 and 55.05%, respectively).

Techniques:

Journal: American Journal of Medicine Open

Article Title: Prevalence and Clinical Burden of Idiopathic Dilated Cardiomyopathy in the United States

doi: 10.1016/j.ajmo.2023.100038

Figure Lengend Snippet: Comorbidities Among Dilated Cardiomyopathy Cases in the Optum EHR Database, 2017-2019

Article Snippet: Rates of diabetes and hypertension (17.9% and 51.7%, respectively) were lower in the UK Clinical Practice Research Datalink cohort, relative to the DCM population in the US Optum EHR (27.39 and 55.05%, respectively).

Techniques: